It is possible for the calibration coefficients to prevent future calibration / alignment if a bad alignment is done on a sensor. If it is desired to reset the calibration coefficients of a sensor to factory values follow this menu path: ; <Settings>, <More>, <Cal>, <View/Edit Cal>, select the sensor and manually change the coefficients so C0 = 0 and C1 = 1. Save the changes. Then a new calibration / alignment can be done per the 4322 Manual.
Contact Fluke Calibration Pressure Technical Support at the below link or by calling +1.877.355.3225